Progress in delivering evidence-based clinical nutrition care has advanced significantly in high-resource settings. However, practice guidelines are not always globally relevant, especially for those working in low- or middle-income countries. There are significant gaps in nutrition care in resource-constrained contexts where specialty services, supplies and equipment, and skilled personnel may not be available to support comprehensive nutrition screening, assessment, and care. We will discuss the current priorities for infant and child nutrition in global health and development, describe the unique intersection of global health nutrition and clinical nutrition care, and highlight the persistent challenges in applying the best practices in resource-limited contexts. Additionally, we will present how one international non-governmental organization, Operation Smile, has integrated clinical nutrition approaches into interdisciplinary care for pediatric patients with cleft conditions in preparation for surgical interventions. Clinical nutrition care in global health is a nascent field, but its advancement to support nutrition care as a human right is vital. While efforts have been made to develop contextually relevant care protocols, there is a lack of global standards and consensus to support those working in settings where clinical nutrition expertise, monitoring tools, nutrition support modalities, and other resources are not available.